The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo

MJ McHugh; PD McGorry; HP Yuen; IB Hickie; A Thompson; L de Haan; N Mossaheb; S Smesny; A Lin; C Markulev; M Schloegelhofer; SJ Wood; D Nieman; JA Hartmann; M Nordentoft; M Schäfer; GP Amminger; A Yung; B Nelson

Journal article

The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo

MJ McHugh, PD McGorry, HP Yuen, IB Hickie, A Thompson, L de Haan, N Mossaheb, S Smesny, A Lin, C Markulev, M Schloegelhofer, SJ Wood, D Nieman, JA Hartmann, M Nordentoft, M Schäfer, GP Amminger, A Yung, B Nelson

Schizophrenia Research | ELSEVIER | Published : 2018

DOI: 10.1016/j.schres.2017.09.003

Abstract

Individuals are considered Ultra-High-Risk (UHR) for psychosis if they meet a set of standardised criteria including presumed genetic vulnerability (Trait), or a recent history of Attenuated Psychotic Symptoms (APS) or Brief Limited Intermittent Psychotic Symptoms (BLIPS). Recent calls to revise these criteria have arisen from evidence that Trait, APS and BLIPS groups may transition to psychosis at different rates. Concurrently, it has become clear that the UHR status confers clinical risk beyond transition to psychosis. Specifically, most UHR individuals will not develop psychosis, but will experience high rates of non-psychotic disorders, persistent APS and poor long-term functional outcom..

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University of Melbourne Researchers

Patrick McGorry Author

Hok Yuen Author

Andrew Thompson Author

Connie Markulev Author

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Grants

Awarded by Stanley Medical Research Institute

Funding Acknowledgements

This work was funded by the Colonial Foundation Philanthropic Trust; Stanley Medical Research Institute (#07TGF-1102 f), and National Health and Medical Research Council Program Grant (#566529 and #350241). The Authors have declared that there are no conflicts of interest in relation to the subject of this study.